To evaluate whether smoked marijuana reduces pain in people with HIV-related peripheral neuropathy.
INCLUSION CRITERIA: * HIV positive. * Be 18 years or older. * Diagnosis of HIV-related painful neuropathy. * Stable antiretroviral therapy or no antiretroviral therapy for at least 8 weeks. * Prior use of marijuana, at least 6 occasions in their lifetime prior to enrollment. EXCLUSION CRITERIA: (Not allowed) * Current use of smoked tobacco products. * Current methadone treatment. * Use of smoked marijuana within 30 days of enrollment. * Diagnosis of diabetes mellitus. * Currently receiving treatment with corticosteroids. * Use of INH, dapsone or metronidazole within 8 weeks prior to enrollment. * Severe heart disease, uncontrolled high blood pressure or lung disease. * Women who are pregnant or breastfeeding.