The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.
Inclusion Criteria: * Essential hypertension (blood pressure \> 140/90) with no signs of secondary hypertension * P-creatinine \< 200 µmol/L Exclusion Criteria: * Anamnestic or clinical signs of heart disease, renal disease, liver disease, neoplastic disease, anemia or cerebro-vascular insult * Medication except antihypertensives * Drug or alcohol abuse * Pregnancy
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