The drugs GSK189075 and GW869682 result in increased caloric losses. This study is investigating how if taken over 8 weeks that affects weight loss, food intake and the composition of the body. The body composition (fat,water, lean mass) is determined using a new investigational MR technology.
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Inclusion criteria: * BMI of 30 - 40kg/m * Females may be included if they are surgically sterile or post-menopausal Exclusion criteria: * Change in body weight \>4% in the last 3 months * History of eating disorders * had bariatric surgical intervention for obesity * have type I or II diabetes * Thyroid disorder not under control * Renal or hepatobiliary disease * Excessive alcohol consumption * Use of drugs of abuse * donated of blood in the last 3 months