NCT01219244COMPLETEDPhase 2Phase 3

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

The study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.

Sponsor

Charite University, Berlin, Germany

Enrollment

330 participants

Sites

1 locations

Start Date

August 2010

Completion

July 2016

Mild Cognitive Impairmentcaloric restrictionomega-3 supplementationresveratrol supplementation

View on ClinicalTrials.gov

Primary Outcomes

Alzheimer's Disease Assessment Scale - cognitive subscale

Prior to intervention and after 6 months of intervention

Eligibility

Min Age

50 Years

Max Age

80 Years

Sex

all

Healthy Volunteers

View full criteria

Inclusion Criteria:

* subjects with mild cognitive impairment
* 50-80 years old
* moderate to heavy weight (BMI 25-35)

Exclusion Criteria:

* dementia
* diabetes
* severe disease
* younger than 50 years
* BMI \< 25

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment.

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.NeuroImage2018

DOI PubMed

Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment.

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.Frontiers in neuroscience2022

DOI PubMed

Impact of leptin on memory function and hippocampal structure in mild cognitive impairment.

Witte A Veronica, Köbe Theresa, Graunke Anders et al.Human brain mapping2018

DOI PubMed

Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients.

Wirth Miranka, Pichet Binette Alexa, Brunecker Peter et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

DOI PubMed

Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.The American journal of clinical nutrition2016

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Fetching protocol from ClinicalTrials.gov…

NCT01219244COMPLETEDPhase 2Phase 3

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

The study will investigate whether dietary modification could provide positive effects on brain functions in elderly people with mild cognitive impairment.

Sponsor

Charite University, Berlin, Germany

Enrollment

330 participants

Sites

1 locations

Start Date

August 2010

Completion

July 2016

Mild Cognitive Impairmentcaloric restrictionomega-3 supplementationresveratrol supplementation

View on ClinicalTrials.gov

Primary Outcomes

Alzheimer's Disease Assessment Scale - cognitive subscale

Prior to intervention and after 6 months of intervention

Eligibility

Min Age

50 Years

Max Age

80 Years

Sex

all

Healthy Volunteers

View full criteria

Inclusion Criteria:

* subjects with mild cognitive impairment
* 50-80 years old
* moderate to heavy weight (BMI 25-35)

Exclusion Criteria:

* dementia
* diabetes
* severe disease
* younger than 50 years
* BMI \< 25

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.NeuroImage2018

DOI PubMed

Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment.

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.Frontiers in neuroscience2022

DOI PubMed

Impact of leptin on memory function and hippocampal structure in mild cognitive impairment.

Witte A Veronica, Köbe Theresa, Graunke Anders et al.Human brain mapping2018

DOI PubMed

Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients.

Wirth Miranka, Pichet Binette Alexa, Brunecker Peter et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

DOI PubMed

Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.

Köbe Theresa, Witte A Veronica, Schnelle Ariane et al.The American journal of clinical nutrition2016

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Primary Outcomes

Eligibility

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Primary Outcomes

Eligibility

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Trial Sites (1)