This study is conducted to investigate the therapeutic efficacy and safety of transcranial direct current stimulation (tDCS) over the primary motor cortex of patients with acute migraine attack.
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Inclusion Criteria: * Aged 17-70 years * Migraine * With or without aura * The first attack of migraine was earlier than 50 years of age * One to 8 moderate to severe migraine attacks per month in the 2 months preceding the screening * Willing and able to give written informed consent * Able to read, comprehend and complete the diary form Exclusion Criteria: * Not able to distinguish between migraine and non-migraine headache * Combined headache, including the tension type headache and medication overuse headache * Pregnant, actively trying to become pregnant or breast-feeding women * Uncontrolled and significant medical illness * Vertebrobasilar or hemiplegic migraine according to the International Headache Society diagnostic criteria * Having intracranial metal implants or a cardiac pacemaker * A history of epilepsy or other organic brain disorders * A history of psychological diseases * Having changed medications for migraine within 1 month before giving us informed consent * Drug abuser or alcoholics