This study is being offered to patients who have hormone resistant prostate cancer (HRPC). This means that their prostate cancer is no longer responding to standard hormonal therapy. The purpose of this study is to determine whether Degarelix will be able to stop the PSA from rising in patients with hormone resistant prostate cancer.
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Inclusion Criteria: * Prior trial of total androgen blockade * Confirmed biochemical PSA progression on agonist therapy, defined as ≥ 50% increase in PSA between 2 measurements, taken at least 1 week apart. In patients that are currently on total androgen blockade (LHRH agonist plus non-steroidal anti-androgen) there must be a trial withdrawal of androgen receptor antagonists to ensure that there is no PSA response (6 weeks for bicalutamide and 4 weeks for flutamide or nilutamide). * Radiologically confirmed non-metastatic disease within 90 days of registration based on negative chest radiographs, CT Scan Abdomen/Pelvis and Bone scan * ECOG ≤ 2 * Age ≥ 18 years * Serum testosterone of ≤ 50 mg/dl * PSA ≥ 2.0 ng/ml * White blood cell count ≥ 3000/mm3 * Platelets ≥ 100,000/mm3 * Serum creatinine ≤ 1.5 x upper limits of normal * Bilirubin ≤ 1.5 x upper limits of normal * Alanine transaminase ≤ 1.25 x upper limits of normal * Estimated life expectancy of at least 12 months * Able and willing to sign informed consent Exclusion Criteria: * Prior treatment with chemotherapy, radiopharmaceuticals, estrogen, PC-SPES, ketoconazole or other second line hormonal therapy (other than non-steroidal anti-androgens or Androcur) * Known allergy to GnRH agonists or antagonists * Previous treatment with Degarelix * Major surgery within 4 weeks of registration * Grade ≥ 3 peripheral neuropathy * Severe, active co-morbidity such as unstable angina, congestive heart failure or myocardial infarction within the last 6 months or congenital long QT syndrome * Acute deep vein thrombosis or pulmonary embolism * Taking anti-arrhythmia medication * Second malignancy other than non-melanoma skin cancer unless disease free ≥ 5 years. * Prior orchiectomy for prostate cancer * PSA \> 100 ng/mL