Set the pattern of vitamin D supplementation in obese patients undergoing bariatric surgery in deficit of vitamin D. Patients receive a single oral dose of vitamin D, during the 28 days will be done a kinetic curve. Then and over the next 3 months, levels are normalized. Once normalized, will be administered another single oral dose to a second pharmacokinetic evaluation.
No linked publications found in PubMed
Inclusion Criteria: * 18 or more years old * with bariatric surgery in the last 18 months (+/- 6 months) * BMI: 25-33 kg/m2 * vitamin D3 (OK)\<20ng/mL. * Clinically stable, in the opinion of the investigator, at the time of inclusion * Signed consent form Exclusion Criteria: * pregnancy, lactation or intention during the study period. * menopause * GOP, GPT\>2 UNL * glomerular filtration rate \<60ml/min * previous renal lithiasis * any digestive disease to suggest malabsorption, granulomatous diseases, diabetic gastroenteropathy and taking medication likely to interfere with the absorption of vitamin D and bone metabolism such as corticosteroids and anticonvulsants * taking medication that interferes with calcium metabolism. * cholecalciferol hypersensitivity. * other bariatric surgery (different of by-pass or tubular gastrectomy)