This is a prospective cohort study assessing measures of cardiometabolic status, body composition, IR and GH response to stimulation after therapy in children (age 7-21 years) treated for ALL. Patients and sibling controls will be recruited from the Pediatric Hematology-Oncology Clinic at the University of Minnesota Amplatz Children's Hospital.
No linked publications found in PubMed
Inclusion Criteria: * Patients * Age 7 years to less than or equal to 21 years at time of study enrollment. * Acute lymphoblastic leukemia (ALL) as first cancer diagnosis and in first complete remission. Any subtype is eligible. * Study enrollment must take place at/after six months of completion of all chemotherapy. * Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2. Use Karnofsky for patients \> 16 years of age and Lansky for patients ≤ 16 years of age. * Any prior ALL therapy is allowable. * Siblings * Age 7 years to less than or equal to 21 years at time of study enrollment. * Sibling of ALL patient. Exclusion Criteria: * Patients * Diagnosis of diabetes mellitus prior to ALL diagnosis or at time of study enrollment. * Current pregnancy * Prior hematopoietic cell transplant. * Receiving growth hormone replacement or corticosteroids at the time of enrollment. * Siblings * Previously diagnosed with malignancy. * Diagnosis of diabetes mellitus. * Current pregnancy * Receiving growth hormone replacement or corticosteroids at the time of enrollment.