NCT02232997COMPLETEDNANo well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients. The investigators will compare long term hydration at routine speed(12h before and after procedure at 1ml/kg/h) with short term hydration at high speed(1h before and 4h after procedure at 3ml/kg/h) to verify our hypothesis that the short term hydration may not be inferior to the long one.
Inclusion Criteria: * ≥18 years of age; * Written informed consent; * Candidates scheduled for coronary intervention (angiography and/or coronary intervention); * Patients with chronic renal insufficiency, the baseline estimated glomerular filtration rate (eGFR) was 15-60 mL/min / 1.73 m² * At least one risk factor (age\>75 years, medical history of diabetes mellitus or hypertension, congestive heart failure \[NYHA class \>II or history of acute pulmonary edema\]); Exclusion Criteria: * End-stage renal failure or heart/renal transplantation; * History of exposure to contrast medium or acute infectious diseases within 48 hours prior to the procedure; * Acute decompensated heart failure; * Left ventricular thrombus; * Allergy to contrast agent; * Pregnancy or lactation; * Malignant tumour or life expectancy \<1 year; * Pre-procedural receipt of NSAIDs (except Asprin), aminoglycosides, cyclosporine or cisplatin in the past 48 h; * Severe valve disease or elective undergoing surgery.
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