To compare the efficacy and safety of Carvedilol and Propranolol in patients with cirrhosis-related esophagogastric varices after multiple endoscopic treatments for secondary prophylaxis.
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Inclusion Criteria: * age between 18-70 years old; * cirrhotic patients referred to Zhongshan Hospital with esophagogastric varices confirmed by endoscopy; * history of variceal bleeding; at least 3 times of endoscopic treatment; * with 1) mild esophageal varices;2) gastric varices with a diameter less than 5mm; or 3) variceal eradication at the time of recruiting. Exclusion Criteria: Patients are excluded when they have * episodes of variceal bleeding after the last endoscopic treatment; * diagnosis of hepatic cellular carcinoma; * severe systemic diseases; * refractory ascites; * contraindication to Carvedilol or Propranolol, such as: asthma, chronic obstructive pulmonary disease, allergic rhinitis, New York Heart Association IV chronic heart failure, atrioventricular blockade, severe bradycardia(HR\<50bpm), sick sinus syndrome, cardiogenic shock, severe hypotension(ABPsys\<85mmHg); * previous and continued use of β-blockers; * Child -Pugh Class C.