Study design: Investigator initiated, single centre, feasibility study Main objectives are twofold: 1. To investigate the feasibility of RNS in patients with therapy resistant hypertension, which is assessing the functional distribution of renal nerves using 3D imaging and differential pacing modalities. 2. To investigate the blood pressure responses and cardiac excitable properties to RNS, and subsequently perform a RDN procedure, guided by 3D mapping by two different techniques e.g. RNS-checked RDN and RNS-guided RDN procedures. Study population: 40 patients (18 - 80 yr old)
Inclusion Criteria: * The patient is willing and able to comply with the protocol and has provided written informed consent. * Age 18-80 years * The patient has hypertension and is accepted for renal denervation or combined pulmonary bein isolation and renal denervation * Glomerular filtration rate \>45 mL/min * No history of renal artery stenosis Exclusion Criteria: * Type 1 diabetes mellitus * Contraindication to chronic anticoagulation therapy or heparin. * Chronic oxygen use * Primary pulmonary hypertension * Woman currently pregnant or breastfeeding or not using reliable contraceptive measures during fertile age. * Known secondary cause of hypertension * Mental or physical inability to participate in the study. * Renal artery stenosis \>50% of the arterial lumen, or renal artery lumen ≤3 mm. * Dual or triple ipsilateral renal artery ostia.