NCT02673762UNKNOWNN/AA PRoBE design study will be used to obtain saliva from patients before undergoing blood study evaluation for screening at risk patients for the presence of undiagnosed pre-diabetes of type II diabetes. Pre-specified saliva biomarkers will be evaluated along with multi-marker models for their discriminatory value for distinguishing patients with normal glucose metabolism from those with disease. Appropriate housekeeping genes will also be incorporated to allow for the measurement of relative gene expression.
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Inclusion Criteria: * Adult patients with unknown glucose metabolism status and * Requiring clinically driven screening for abnormal glucose metabolism and * Outpatient status Exclusion Criteria: * Patients on treatment for abnormal glucose metabolism including diet and drug therapy * Patients with a prior diagnosis of abnormal glucose metabolism * Patients on treatment with corticosteroids