NCT03673956COMPLETEDResults postedPhase 1Phase 2Researchers are trying to find out if patients develop antibiotic resistant organisms after the use of topical antibiotics in the treatment of chronic rhinosinusitis.
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Inclusion Criteria: * Male or female, between 18-80 years old, diagnosed with chronic rhinosinusitis who have undergone previous functional endoscopic sinus surgery including at minimum maxillary antrostomy and anterior ethmoidectomy * Active mucopurulence on endoscopic examination with corresponding culture demonstrating pathogenic bacterial growth * Completion of written informed consent * No prior enrollment into this study * Refractory to maximal medical therapy Exclusion Criteria: * Patient has not had prior endoscopic sinus surgery consisting of at minimum maxillary antrostomy and anterior ethmoidectomy * Patient is currently being treated with oral antibiotics * Patient has been treated with oral or topical antibiotics within the past 14 days * Participation in an investigational drug study simultaneously with participation in this study * Concurrent use of oral steroids * Allergy to Tobramycin, Mupirocin, Gentamicin and Levofloxacin * Known to currently be pregnant