Statins, a major class of drugs for treatment of hypercholesterolemia, are widely used due to a notable prevention of cardiovascular disease, and accumulating evidence proposes a promising role of statins in breast cancer
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Inclusion Criteria: 1. Confirmed breast cancer any stage confirmed by radiological and pathological or by clinical evaluation undergo surgery or receiving neo/adjuvant chemotherapy treatment 2. Age above 18 years 3. HER2 negative core biopsy 4. Adequate renal function: the calculated creatinine clearance should be ≥50 mL/min 5. Patients must be accessible for treatment and follow-up 6. Performance status of Eastern Cooperative Oncology Group (ECOG) ≤ 2 Exclusion Criteria: 1. Known hypersensitivity reaction to the investigational compounds or incorporated substances 2. patients who are unlikely to comply with trial requirements (eg, confusion, psychological or mood disturbances ,alcoholism, cardiac arrhythmia)