NCT05349318UNKNOWNNAAlzheimer´s disease is a devastating illness that effects the patients as well as their family members. Its prevalence increases exponentially and the burden on the healthcare system is enormous. AD neuropathology begins 15-20 years before the occurrence of cognitive symptoms, which ranges from preclinical stage to mild cognitive impairment (MCI) to dementia. Prodromal AD is an early stage of the disease which is characterized by positive biomarkers and MCI. To this day, there is no medication that can cure or halt the progression of the disease and most studies focus on finding reversible risk factors and changing their influence. Several aetiologies have been proposed, like the deposition of amyloid and tau proteins, neuroinflammation and cerebral ischemia due to cerebrovascular factors. The Amyloid deposition, which serves as the biological marker of AD, was originally thought to be the main cause of the disease, however, recent data suggests that it is not the cause and that it might actually has a protective role. On the other hand, it is known today that vascular changes with related tissue ischemia and neuroinflammation have a crucial role in the development of AD in many patients. These pathologies, ischemia \& neuroinflammation, can be improved by the use of hyperbaric oxygen therapy (HBOT). The goal of this study is to explore the potential beneficial effect of HBOT on prodromal AD.
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Inclusion Criteria: 1. Diagnosis of Mild cognitive impairment (MCI) due to AD or mixed AD and vascular dementia pathology 2. MMSE score of 20 and above 3. Stable psychological and pharmacological treatment for more than three months prior to inclusion. 4. Caregiver that is seeing the patient at least twice per week and is willing to participate and accompany the patient and fill questionnaires 5. Subject willing and able to read, understand and sign an informed consent Exclusion Criteria: 1. Inability to attend scheduled clinic visits and/or comply with the study protocol 2. History of traumatic brain injury, brain tumors, brain surgery, chronic subdural haemorrhages, Epilepsy 3. Active malignancy 4. Substance use at baseline, except for prescribed cannabis if vaporized or taken PO as tincture 5. History of other neurodegenerative diseases including Parkinson's disease (PD), Lewy body dementia (LBD), Frontotemporal dementia (FTD), Multiple sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Creutzfeld Jacob disease (CJD), Multisystem atrophy (MSA), Pseudobulbar palsy (PSP), Corticobasal degeneration (CBD), Wernicke Korsakoff syndrome 6. Chronic use of medications that may compromise cognitive function and cannot be stopped: Anticonvulsants, Anticholinergics, antiparkinsonian, corticosteroids, Benzodiazepines 7. Moderate to severe sleep apnea with no use of CPAP 8. Diagnosis of a psychiatric disorder including: major depression, schizophrenia, bipolar disorder 9. Serious suicidal ideation 10. Renal or liver insufficiency, electrolyte imbalances 11. Chronic heart failure with ejection fraction of 35 or less 12. HBOT for any reason prior to study enrolment 13. Chest pathology incompatible with pressure changes (including active asthma or COPD) 14. Ear or Sinus pathology incompatible with pressure changes (above 3 otolaryngologist visits a year) 15. An inability to perform an awake brain MRI or Amyloid PET 16. An inability to perform computerized cognitive tests (Neurotrax) 17. MMSE score below 20 18. No evidence of amyloid in the brain PET 19. No evidence of vascular related lesions in the brain MRI 20. Active smoking 21. Participation in another study