The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
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Inclusion Criteria: 1. Age ≥ 18 years, both sexes; 2. Clinically definite diagnosis of acute ischemic stroke; 3. Baseline National Institute of Health Stroke Scale (NIHSS) score ≤25; 4. Pre-onset modified Rankin Scale (mRS) score ≤1; 5. Randomized and initiated transcranial magnetic stimulation within 1 week of onset; 6. Subject or legal representative agreed to the treatment and signed the informed consent. Exclusion Criteria: 1. Presence of a medical condition such as severe cognitive impairment or mental impairment; 2. Patients with serious physical diseases or who have had craniocerebral surgery; 3. Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors; 4. Pregnancy or breastfeeding; 5. The presence of metal foreign bodies near the stimulation site, such as intracranial metal implants, cochlear implants, built-in pulse generators (brain pacemakers, cardiac pacemakers), etc.; 6. Patients who are unable to complete cerebral autoregulation, or bilateral temporal window penetration poorly; 7. life expectancy of ≤3 months or inability to complete the study for other reasons; 8. unwillingness to be followed up or poor treatment compliance; 9. Those who are participating in other clinical investigators, or who have participated in other clinical studies within 3 months prior to enrollment, or who have participated in this study; 10. Other conditions that the investigators deemed unsuitable for enrollment.