The goal of this research study is to determine if the DigniCap Scalp Cooling System can help prevent chemotherapy-induced hair loss in Black patients.
Inclusion Criteria: * Diagnosed with early stage breast cancer (stage I-III) * Self-identify as Black * Planned therapy with taxane and/or anthracycline-based chemotherapy (at least 4 cycles must be planned) -≥ 21 years of age * Able to give informed consent Exclusion Criteria: * Female pattern hair loss or hair loss disorder * Scalp folliculitis * Scalp psoriasis Scalp seborrheic dermatitis * Inflammatory scalp conditions such as lichen planopillaris or alopecia areata * Subjects wearing wigs or subjects who shave their hair prior to chemotherapy * Unable to provide consent or make allotted clinical visits * Subjects with cold agglutinin disease or cold urticaria * Unwilling to remove hair extensions during treatment phase which can interfere with study assessments * History or whole brain irradiation * History of prior systemic chemotherapy