RECRUITINGN/A

Vitreopapillary Interface and Optic Disc Morphology

The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH). With formation of a stepwise posterior vitreous detachment (PVD) exerted tractional forces could influence retinal functioning. Especially in patients with glaucoma the influence of vitreous traction to the ONH could mask progression, interfere with current imaging techniques and even be a cause of ONH hemorrhages. Therefore the aim of this study is to investigate whether vitreopapillary traction has a significant effect on diagnosis and follow up of glaucoma patients.

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

350 participants

Sites

1 locations

Start Date

November 2014

Completion

April 2025

Posterior Vitreous DetachmentVitreomacular TractionGlaucomaVitreopapillary TractionOCT imaging/HRT imaging

Enrollment & Timeline

Recruiting

Target enrollment (estimated)

Target N

350

participants

Sites

locations

Duration

10.8 years

total trial span

Rate

pts/month needed

Nov 2014Month 137 of 129Apr 2025

100% of trial timeline elapsed

At 1 sites, each site needs to enroll approximately 3.0 patients/month to hit the enrollment target on schedule.

Enrollment target is estimated. ClinicalTrials.gov does not provide real-time enrollment progress.

View on ClinicalTrials.gov

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Primary Outcomes

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Peripapillary retinal nerve fiber layer thickening associated with vitreopapillary traction.

Hwang Young Hoon, Kim Yong YeonSeminars in ophthalmology2015

DOI PubMed

Vitreopapillary traction in eyes with idiopathic epiretinal membrane: a spectral-domain optical coherence tomography study.

Kim Yong Woo, Jeoung Jin Wook, Yu Hyeong GonOphthalmology2014

DOI PubMed

The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study.

Willekens Koen, Abegão Pinto Luìs, Lemmens Sophie et al.Acta ophthalmologica2018

DOI PubMed

Vitreopapillary traction as a cause of elevated optic nerve head.

Wisotsky B J, Magat-Gordon C B, Puklin J EAmerican journal of ophthalmology1998

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Fetching protocol from ClinicalTrials.gov…

RECRUITINGN/A

Vitreopapillary Interface and Optic Disc Morphology

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

350 participants

Sites

1 locations

Start Date

November 2014

Completion

April 2025

Posterior Vitreous DetachmentVitreomacular TractionGlaucomaVitreopapillary TractionOCT imaging/HRT imaging

Enrollment & Timeline

Recruiting

Target enrollment (estimated)

Target N

350

participants

Sites

locations

Duration

10.8 years

total trial span

Rate

pts/month needed

Nov 2014Month 137 of 129Apr 2025

100% of trial timeline elapsed

At 1 sites, each site needs to enroll approximately 3.0 patients/month to hit the enrollment target on schedule.

Enrollment target is estimated. ClinicalTrials.gov does not provide real-time enrollment progress.

View on ClinicalTrials.gov

Ask AI

Primary Outcomes

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Peripapillary retinal nerve fiber layer thickening associated with vitreopapillary traction.

Hwang Young Hoon, Kim Yong YeonSeminars in ophthalmology2015

DOI PubMed

Vitreopapillary traction in eyes with idiopathic epiretinal membrane: a spectral-domain optical coherence tomography study.

Kim Yong Woo, Jeoung Jin Wook, Yu Hyeong GonOphthalmology2014

DOI PubMed

The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study.

Willekens Koen, Abegão Pinto Luìs, Lemmens Sophie et al.Acta ophthalmologica2018

DOI PubMed

Vitreopapillary traction as a cause of elevated optic nerve head.

Wisotsky B J, Magat-Gordon C B, Puklin J EAmerican journal of ophthalmology1998

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Prevalence of VPT in glaucoma patients

From inclusion up to 17 months

Percentage of patients diagnosed with glaucoma who have Vitreopapillary traction.

Change in VPT following trabeculectomy

From inclusion up to 17 months with an average follow up of 8 weeks per subject

To investigate whether the sudden decrease in intraocular pressure following trabeculectomy has a significant effect on ONH morphology (mean retinal nerve fiber layer (mRNFL) thickness, cup volume, rim thickness, cup/disc ratio) caused by change in VPT. Patients scheduled for trabeculectomy will have a baseline visit up until 8 weeks before the surgery and 4 post operative visits (day 1, week 1, 2 and 4)

Change in VPT following ocriplasmin

From inclusion up to 17 months with an average follow up of 8 weeks per subject

To investigate whether the use of Ocriplasmin has a significant effect on ONH morphology (mRNFL thickness, cup volume, rim thickness, cup/disc ratio) caused by change in VPT. Patients scheduled for Ocriplasmin treatment will have a baseline visit 1 week before the surgery and 2 post operative visits (day 1, week 4)

Vitreopapillary Interface and Optic Disc Morphology

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Vitreopapillary Interface and Optic Disc Morphology

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Eligibility

Trial Sites (1)