ENROLLING BY INVITATIONN/A

Development of Obesity and Bariatric Surgery

This study focus on the cause of obesity and impacts of bariatric surgery on it.

Sponsor

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Enrollment

150 participants

Sites

1 locations

Start Date

March 2017

Completion

March 2025

Obesity

Enrollment & Timeline

ENROLLING BY INVITATION

Target enrollment (estimated)

Target N

150

participants

Sites

locations

Duration

8.3 years

total trial span

Rate

pts/month needed

Mar 2017Month 109 of 99Mar 2025

100% of trial timeline elapsed

At 1 sites, each site needs to enroll approximately 2.0 patients/month to hit the enrollment target on schedule.

Enrollment target is estimated. ClinicalTrials.gov does not provide real-time enrollment progress.

View on ClinicalTrials.gov

Ask AI

Primary Outcomes

Immunity cells

up to 5 years

Ratio of immunity cells in circulating and adipose or liver tissue

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Prolactin improves hepatic steatosis via CD36 pathway.

Zhang Pengzi, Ge Zhijuan, Wang Hongdong et al.Journal of hepatology2019

DOI PubMed

Hepatic expression of Yin Yang 1 (YY1) is associated with the non-alcoholic fatty liver disease (NAFLD) progression in patients undergoing bariatric surgery.

Yuan Xianwen, Chen Jun, Cheng Qi et al.BMC gastroenterology2018

DOI PubMed

Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and Type 2 Diabetes.

Liu Fangcen, He Jielei, Liu Boxun et al.Obesity (Silver Spring, Md.)2021

DOI PubMed

Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus.

Tang Wenjuan, Ge Kang, Shen Lei et al.Diabetes/metabolism research and reviews2023

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Fetching protocol from ClinicalTrials.gov…

ENROLLING BY INVITATIONN/A

Development of Obesity and Bariatric Surgery

This study focus on the cause of obesity and impacts of bariatric surgery on it.

Sponsor

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Enrollment

150 participants

Sites

1 locations

Start Date

March 2017

Completion

March 2025

Obesity

Enrollment & Timeline

ENROLLING BY INVITATION

Target enrollment (estimated)

Target N

150

participants

Sites

locations

Duration

8.3 years

total trial span

Rate

pts/month needed

Mar 2017Month 109 of 99Mar 2025

100% of trial timeline elapsed

At 1 sites, each site needs to enroll approximately 2.0 patients/month to hit the enrollment target on schedule.

Enrollment target is estimated. ClinicalTrials.gov does not provide real-time enrollment progress.

View on ClinicalTrials.gov

Ask AI

Primary Outcomes

Immunity cells

up to 5 years

Ratio of immunity cells in circulating and adipose or liver tissue

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Prolactin improves hepatic steatosis via CD36 pathway.

Zhang Pengzi, Ge Zhijuan, Wang Hongdong et al.Journal of hepatology2019

DOI PubMed

Hepatic expression of Yin Yang 1 (YY1) is associated with the non-alcoholic fatty liver disease (NAFLD) progression in patients undergoing bariatric surgery.

Yuan Xianwen, Chen Jun, Cheng Qi et al.BMC gastroenterology2018

DOI PubMed

Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and Type 2 Diabetes.

Liu Fangcen, He Jielei, Liu Boxun et al.Obesity (Silver Spring, Md.)2021

DOI PubMed

Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus.

Tang Wenjuan, Ge Kang, Shen Lei et al.Diabetes/metabolism research and reviews2023

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

all

Healthy Volunteers

Yes

View full criteria

Inclusion Criteria:

1. Body mass index ≥18 kg/m2
2. already received bariatric surgery or abdonimal surgery

Exclusion Criteria:

1. acute stroke or acute myocardial infarction in 6 months
2. autoimmune disease
3. long-term use of non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressive drugs
4. pregnancy
5. consists with other endocrine diseases
6. acute infection in2 weeks
7. cancer
8. use of antibiotics in 3 months
9. chronic digestive inflammations 9

Development of Obesity and Bariatric Surgery

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Development of Obesity and Bariatric Surgery

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Eligibility

Trial Sites (1)