This study is meant to compare the amount of oxygen required for hypoxemia relief between current standard of care (oxygen only) and oxygen with the addition of high flow air for Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease (ILD), and Pulmonary Hypertension (PH) patients during rest. Subjects will be titrated from 0 L/min until they maintain 95% SpO2 for each of the following delivery methods: 1. Pulses of pure oxygen (control) 2. Constant high flow air with pulses of pure oxygen 3. Out of phase pulses of high flow air and pure oxygen
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Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged greater or equal to 30 years old * Require Long Term Oxygen Therapy between 1 L/min and 4 L/min while at rest * Have a peripheral blood saturation level above 80% with room air while seated * Tolerate breathing while seated in room air * Diagnosed with one of the following respiratory diseases: COPD (40% \< Forced Expiratory Volume (FEV1) \< 80% confirmed from pulmonary function test (PFT) within the last year), ILD (Confirmed with radiographic imaging), PH (Confirmed with radiographic imaging) * Normal heart rate and blood pressure (Resting Heart Rate \<120 bpm, Systolic BP \<180 mmHg, Diastolic BP \<100mmHg) * PFT taken in the last three months Exclusion Criteria: * Pregnancy or lactation * Exacerbation that has resolved within the past 28 days * Treatment with another investigational drug or other intervention within three months * Has any of the following: unstable angina, recent revascularization, recent history of cerebrovascular accident