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Explore/Alzheimer's disease MCI prevention

Status

Phase

Pre-filtered to show active, later-stage trials with the strongest clinical signal.

26 results for “Alzheimer's disease MCI prevention” · Phase 3 · Phase 2

Page 1 of 2

Completed

Results posted

The Efficient Brain Study

Phase 2Metabolism - Cerebral Energy

Fermented Papaya PreparationGranulated Sugar

University of Florida30 participants1 site · United StatesCompletes Jul 2018

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Completed

Results posted

Tau Imaging of Chronic Traumatic Encephalopathy

Phase 2Chronic Traumatic Encephalopathy

[F18]-T807[F18]-FlorbetapirMRI/MRS+1 more

Brigham and Women's Hospital30 participants2 sites · United StatesCompletes Sep 2016

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UNKNOWN

Disease-modifying Properties of Lithium in the Neurobiology of Alzheimer's Disease

Phase 2Cognitive ImpairmentAlzheimer Disease

Lithium CarbonatePlacebo

University of Sao Paulo80 participants1 site · BrazilCompletes Mar 2009

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Completed

Results posted

Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI)

Phase 3Post-Stroke Cognitive Impairment (PSCI)

ActoveginPlacebo

Takeda503 participants14 sites · Belarus, Kazakhstan, RussiaCompletes Nov 2014

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Not Yet Recruiting

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentCognitive Decline

Resveratrol, Quercetin, and Curcumin (RQC)Curcumin

Zaparackas and Knepper LTD200 participants1 site · United StatesCompletes Jul 2027

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Completed

Results posted

Valacyclovir for Mild Cognitive Impairment

Phase 2Mild Cognitive ImpairmentHerpes Simplex 1Herpes Simplex 2

Valacyclovir hydrochloride 500mg capletPlacebo sugar pill caplet

New York State Psychiatric Institute50 participants1 site · United StatesCompletes Oct 2024

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Active

Metformin in Alzheimer's Dementia Prevention

Phase 2Phase 3Mild Cognitive Impairment

Placebo oral tabletextended release metformin

Columbia University326 participants22 sites · United StatesCompletes Apr 2026

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Recruiting

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

Phase 2InsomniaCognitive DysfunctionMild Cognitive Impairment

SHUTi OASISPatient Education

University of Virginia144 participants1 site · United StatesCompletes Jan 2028

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Recruiting

ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

Phase 2Cognitive DysfunctionAlzheimer DiseaseBlood-Brain Barrier

Alpha-Linolenic Acid (2.6 g/day)Placebo Control Group

Michal Schnaider Beeri, Ph.D.20 participants1 site · United StatesCompletes Apr 2027

Compare CT.gov Full analysis →

UNKNOWN

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Phase 2Mild Cognitive Impairment

Curcuminaerobic yoganon aerobic yoga+1 more

VA Office of Research and Development80 participants1 site · United StatesCompletes Mar 2020

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Completed

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Phase 2Phase 3Mild Cognitive Impairment

caloric restrictionomega-3 supplementationresveratrol supplementation+3 more

Charite University, Berlin, Germany330 participants1 site · GermanyCompletes Jul 2016

Compare CT.gov Full analysis →

Completed

Results posted

The Synapse Project

Phase 2Alzheimer Disease

UCB-JMRI ScanPET Scan

University of Wisconsin, Madison100 participants1 site · United StatesCompletes Oct 2023

Compare CT.gov Full analysis →

Completed

Memory Impairment Study (Mild Cognitive Impairment Study)

Phase 3Alzheimer Disease

DonepezilVitamin E

National Institute on Aging (NIA)72 sites · United States, CanadaCompletes Jan 2004

Compare CT.gov Full analysis →

Terminated

Investigating the Clinical Consequences of Flutemetamol-PET-scanning

Phase 3Mild Cognitive ImpairmentAlzheimer's DiseaseDementia

Flutemetamol (Vizamyl)

University of Zurich11 participants1 site · SwitzerlandCompletes Dec 2019

Compare CT.gov Full analysis →

Completed

A Trial of Cilostazol in Patients With Mild Cognitive Impairment (COMCID)

Phase 2Mild Cognitive Impairment

CilostazolPlacebo

National Cerebral and Cardiovascular Center, Japan166 participants1 site · JapanCompletes Aug 2020

Compare CT.gov Full analysis →

1–15 of 26

Explore/Alzheimer's disease MCI prevention

Status

Phase

Pre-filtered to show active, later-stage trials with the strongest clinical signal.

26 results for “Alzheimer's disease MCI prevention” · Phase 3 · Phase 2

Page 1 of 2

Completed

Results posted

The Efficient Brain Study

Phase 2Metabolism - Cerebral Energy

Fermented Papaya PreparationGranulated Sugar

University of Florida30 participants1 site · United StatesCompletes Jul 2018

Compare CT.gov Full analysis →

Completed

Results posted

Tau Imaging of Chronic Traumatic Encephalopathy

Phase 2Chronic Traumatic Encephalopathy

[F18]-T807[F18]-FlorbetapirMRI/MRS+1 more

Brigham and Women's Hospital30 participants2 sites · United StatesCompletes Sep 2016

Compare CT.gov Full analysis →

UNKNOWN

Disease-modifying Properties of Lithium in the Neurobiology of Alzheimer's Disease

Phase 2Cognitive ImpairmentAlzheimer Disease

Lithium CarbonatePlacebo

University of Sao Paulo80 participants1 site · BrazilCompletes Mar 2009

Compare CT.gov Full analysis →

Completed

Results posted

Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI)

Phase 3Post-Stroke Cognitive Impairment (PSCI)

ActoveginPlacebo

Takeda503 participants14 sites · Belarus, Kazakhstan, RussiaCompletes Nov 2014

Compare CT.gov Full analysis →

Not Yet Recruiting

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentCognitive Decline

Resveratrol, Quercetin, and Curcumin (RQC)Curcumin

Zaparackas and Knepper LTD200 participants1 site · United StatesCompletes Jul 2027

Compare CT.gov Full analysis →

Completed

Results posted

Valacyclovir for Mild Cognitive Impairment

Phase 2Mild Cognitive ImpairmentHerpes Simplex 1Herpes Simplex 2

Valacyclovir hydrochloride 500mg capletPlacebo sugar pill caplet

New York State Psychiatric Institute50 participants1 site · United StatesCompletes Oct 2024

Compare CT.gov Full analysis →

Active

Metformin in Alzheimer's Dementia Prevention

Phase 2Phase 3Mild Cognitive Impairment

Placebo oral tabletextended release metformin

Columbia University326 participants22 sites · United StatesCompletes Apr 2026

Compare CT.gov Full analysis →

Recruiting

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

Phase 2InsomniaCognitive DysfunctionMild Cognitive Impairment

SHUTi OASISPatient Education

University of Virginia144 participants1 site · United StatesCompletes Jan 2028

Compare CT.gov Full analysis →

Recruiting

ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

Phase 2Cognitive DysfunctionAlzheimer DiseaseBlood-Brain Barrier

Alpha-Linolenic Acid (2.6 g/day)Placebo Control Group

Michal Schnaider Beeri, Ph.D.20 participants1 site · United StatesCompletes Apr 2027

Compare CT.gov Full analysis →

UNKNOWN

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Phase 2Mild Cognitive Impairment

Curcuminaerobic yoganon aerobic yoga+1 more

VA Office of Research and Development80 participants1 site · United StatesCompletes Mar 2020

Compare CT.gov Full analysis →

Completed

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Phase 2Phase 3Mild Cognitive Impairment

caloric restrictionomega-3 supplementationresveratrol supplementation+3 more

Charite University, Berlin, Germany330 participants1 site · GermanyCompletes Jul 2016

Compare CT.gov Full analysis →

Completed

Results posted

The Synapse Project

Phase 2Alzheimer Disease

UCB-JMRI ScanPET Scan

University of Wisconsin, Madison100 participants1 site · United StatesCompletes Oct 2023

Compare CT.gov Full analysis →

Completed

Memory Impairment Study (Mild Cognitive Impairment Study)

Phase 3Alzheimer Disease

DonepezilVitamin E

National Institute on Aging (NIA)72 sites · United States, CanadaCompletes Jan 2004

Compare CT.gov Full analysis →

Terminated

Investigating the Clinical Consequences of Flutemetamol-PET-scanning

Phase 3Mild Cognitive ImpairmentAlzheimer's DiseaseDementia

Flutemetamol (Vizamyl)

University of Zurich11 participants1 site · SwitzerlandCompletes Dec 2019

Compare CT.gov Full analysis →

Completed

A Trial of Cilostazol in Patients With Mild Cognitive Impairment (COMCID)

Phase 2Mild Cognitive Impairment

CilostazolPlacebo

National Cerebral and Cardiovascular Center, Japan166 participants1 site · JapanCompletes Aug 2020

Compare CT.gov Full analysis →

1–15 of 26